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Updated: Mar 8, 2026

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
A variant of Brugada syndrome
Maryna Popp Switzer1, Mohamed Teleb1, Enoch Agunanne1
1Departments of Internal Medicine (Switzer, Teleb, Agunanne, Abbas) and Cardiology (Teleb, Agunanne, Abbas), Texas Tech University Health Sciences Center, El Paso, Texas.
Abstract:
Brugada syndrome is an inherited disorder that can present with syncope, cardiac arrest, or sudden cardiac death. Multiple genetic mutations have been described that cause this disease. We present a 56-year-old man who sustained an out-of-hospital cardiac arrest, was resuscitated, and was found to have typical features of the Brugada criteria on the electrocardiogram. Genetic testing was positive for a heterozygous mutation in the sodium voltage-gated channel alpha subunit 5 (SCN5A) gene with a p. Leu227Pro (L227P) variant located on exon 6. To our knowledge, this is the first described case with this variant causing malignant arrhythmia with a cardiac arrest.
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