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NOS1-, NOS3-, PIK3CA-, and MAPK-pathways in skin following radiation therapy

Steffen Koerdt1, Nadine Tanner1, Niklas Rommel1

  • 1Department of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.

Biomarker Research
|January 28, 2017
PubMed
Abstract

Insights

Radiation therapy (RT) can impact wound healing. This study found increased MAPK and PIK3CA gene expression in patients with radiation-induced wound healing disorders, suggesting their role in radiation toxicity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Radiotherapy Research

Background:

  • Essential molecular pathways like MAPK, NO system, and PIK3CA are crucial for signaling networks.
  • Limited knowledge exists regarding their specific role in radiation-induced wound healing disorders (WHD).

Purpose of the Study:

  • To evaluate the expression profiles of specific molecular pathway marker genes.
  • To investigate the association between gene expression and the occurrence of WHD following radiation therapy (RT).

Main Methods:

  • Gene expression analysis of MAPK, NOS1, NOS3, and PIK3CA using RT-PCR.
  • Analysis of clinical data on cervical WHD occurrence in head and neck cancer patients with and without RT history.

Main Results:

  • Significant increase in MAPK expression observed in patients with postoperative WHDs compared to controls.
  • Significantly increased PIK3CA expression noted in patients with a history of RT.
  • No significant differences found for other investigated genes.

Conclusions:

  • RT influences molecular pathways, highlighting their role in long-term radiation toxicity like WHDs.
  • Specific molecular networks are crucial for WHD development post-RT.
  • Further research is needed to identify potential therapeutic intervention targets.
Keywords:
MAPKNOSPCRPIK3CARadiation therapy

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