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Related Concept Videos

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Given simple random samples of size n from a given population with a measured characteristic such as mean, proportion, or standard deviation for each sample, the probability distribution of all the measured characteristics is called a sampling distribution. How much the statistic varies from one sample to another is known as the sampling variability of a statistic. You typically measure the sampling variability of a statistic by its standard error. The standard error of the mean is an example...
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Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest. Among the various sampling methods used by...
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Related Experiment Video

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Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
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The meaning of sampling density in multiple repeat prostate biopsies.

Jan Hrbáček1, Otakar Čapoun2, Ivo Minárik1

  • 1Department of Urology, 2 Faculty of Medicine and Motol University Hospital, Charles University Praha, Czech Republic.

Central European Journal of Urology
|January 28, 2017
PubMed
Summary

Increased prostate biopsy sampling density improves cancer detection rates, especially in younger men during their first repeat biopsy. This finding is crucial for optimizing prostate cancer diagnosis and reducing missed cancers.

Keywords:
biopsycancer detectionprostate cancer

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Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Transrectal ultrasound-guided prostate biopsy is standard for prostate cancer detection.
  • Repeat biopsies are often necessary due to missed cancers, occurring in about one-third of cases.

Purpose of the Study:

  • To evaluate the impact of sampling density on cancer detection rates during repeat transrectal ultrasound-guided prostate biopsies.
  • To identify factors influencing detection rates in patients undergoing multiple repeat biopsies.

Main Methods:

  • Analysis of data from 1007 patients undergoing first, second, or further repeat prostate biopsies.
  • Interaction analysis to assess the relationship between sampling density, clinical variables, and cancer detection rate.

Main Results:

  • Cancer detection rates were consistent across primary (25.4%), second (25.8%), and further repeat biopsies (25.3%).
  • Sampling density significantly interacted with age in first repeat biopsies, but not in further repeat biopsies.
  • No significant interactions were found between sampling density and other clinical variables.

Conclusions:

  • Higher prostate sampling density increases cancer detection rates in repeat biopsies.
  • The benefit of increased sampling density is most pronounced in men under 65 undergoing their first repeat biopsy.