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Related Experiment Video

Updated: Feb 21, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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295

Syndromes with cleft lip and cleft palate.

M M Cohen

    The Cleft Palate Journal
    |October 1, 1978
    PubMed
    Summary

    Clinicians can use diagnostic tables to identify syndromes associated with cleft lip and/or palate. These tables help diagnose over 154 recognized orofacial clefting syndromes, aiding in patient diagnosis.

    Area of Science:

    • Medical Genetics
    • Clinical Diagnostics
    • Craniofacial Anomalies

    Background:

    • Orofacial clefts, including cleft lip and/or palate, are common congenital anomalies.
    • A significant number of syndromes are associated with orofacial clefting.
    • The number of recognized syndromes has more than doubled since 1971.

    Purpose of the Study:

    • To provide clinicians with a diagnostic aid for patients presenting with cleft lip and/or palate and associated anomalies.
    • To facilitate the rapid identification of potential syndromes linked to orofacial clefting.
    • To offer a structured approach to diagnosing complex cases.

    Main Methods:

    • Development of a series of diagnostic tables.
    • Categorization of recognized syndromes associated with orofacial clefting.

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  • Systematic sorting of clinical features against known syndrome classifications.

    • Main Results:

    • A comprehensive set of tables is presented as a diagnostic tool.
    • The tables cover 154 recognized syndromes associated with orofacial clefting.
    • The diagnostic aid allows for efficient differential diagnosis.

    Conclusions:

    • The presented tables serve as a valuable resource for clinicians managing patients with cleft lip and/or palate.
    • The diagnostic aid aids in the recognition and classification of a growing number of orofacial clefting syndromes.
    • Continued research is expected to identify further syndromes in the future.