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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
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Desensitization: Overcoming the Immunologic Barriers to Transplantation
Supreet Sethi1, Jua Choi1, Mieko Toyoda1
1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Journal of Immunology Research
|January 28, 2017
Summary
Human Leucocyte Antigen (HLA) sensitization hinders kidney transplants. New immunomodulatory therapies improve access for sensitized patients and may help treat antibody-mediated rejection.
Area of Science:
- Immunology
- Nephrology
- Transplantation Science
Background:
- Human Leucocyte Antigen (HLA) sensitization poses a major challenge for kidney transplantation.
- It leads to difficulties in crossmatching and increases the risk of antibody-mediated rejection post-transplant.
Purpose of the Study:
- To review current immunomodulatory therapies for desensitizing HLA-sensitized kidney transplant candidates.
- To analyze emerging biologics and their potential impact on desensitization and antibody-mediated rejection.
Main Methods:
- Literature review of immunomodulatory agents used in desensitization.
- Analysis of clinical data for available and novel biologic therapies.
Main Results:
- Several classes of immunomodulatory agents are available for desensitization, including IgG inactivating agents, anti-cytokine antibodies, costimulatory molecule blockers, complement inhibitors, and plasma cell-targeting agents.
- Novel biologics show promise for improving desensitization outcomes.
Conclusions:
- Immunomodulatory therapies have expanded kidney transplantation access for HLA-sensitized patients.
- Emerging biologics are expected to further enhance desensitization strategies and offer new treatment options for antibody-mediated rejection.
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