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Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells
Chenfu Liu1, Chao Yang2, Lihua Lu3
1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. edmondma@hkbu.edu.hk.
Chemical Communications (Cambridge, England)
|January 28, 2017
Abstract:
Two luminescent iridium(iii) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium(iii) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.
