Related Experiment Video
Updated: Mar 8, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Passively Transferred Pemphigus in a Newborn
Insights
Neonatal pemphigus, a rare condition, can occur in infants born to mothers with pemphigus. This case shows transient pemphigus-like lesions in a newborn that resolved spontaneously.
Area of Science:
- Dermatology
- Immunology
- Obstetrics
Background:
- Pemphigus is an autoimmune blistering disease.
- Neonatal pemphigus is a rare condition where infants develop pemphigus-like lesions.
- Maternal autoantibodies can cross the placenta, potentially affecting the fetus.
Abstract:
A 24 yew old patient having pemphigus for the last 1 year delivered a female baby after 36 weeks of gestation. The baby had pemphigus like lesions on the skin and a single ulcer on the hard palate. The serum antibody titres of intercellular antibodies in the mother and the baby at the time of delivery were 1:80 and 1: 40 respectively. 1 The lesions in the baby healed completely by the 9th day after birth, without any specific treatment. Three months later the antibody titre in the mother was 1: 40, while in test became negative The baby the baby, the has since shown no recurrence of the lesions.
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