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Dapsone Induced Methaemoglobinemia
Indian Journal of Dermatology, Venereology and Leprology
|January 28, 2017
Summary
Dapsone, a leprosy treatment, can cause methemoglobinemia, a condition reducing oxygen transport. Symptoms like cyanosis and fatigue resolved after discontinuing dapsone.
Area of Science:
- Pharmacology
- Hematology
- Dermatology
Background:
- Dapsone is a key treatment for leprosy.
- Leprosy management requires careful monitoring for adverse effects.
Observation:
- A 33-year-old female developed cyanosis, fatigue, malaise, and headache 3 weeks after starting 100 mg daily dapsone for borderline-tuberculoid leprosy.
- A 15-year-old male exhibited similar symptoms 9 days after initiating 50 mg daily dapsone for suspected indeterminate leprosy.
Findings:
- Both patients presented with drug-induced methemoglobinemia.
- Discontinuation of dapsone led to the reversal of methemoglobinemia in both cases.
Implications:
- This highlights the potential risk of methemoglobinemia with dapsone therapy.
- Clinicians should be vigilant for methemoglobinemia symptoms in patients treated with dapsone.
- Early recognition and dapsone withdrawal are crucial for managing this adverse effect.
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