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    Area of Science:

    • Pharmacology
    • Hematology
    • Dermatology

    Background:

    • Dapsone is a key treatment for leprosy.
    • Leprosy management requires careful monitoring for adverse effects.

    Observation:

    • A 33-year-old female developed cyanosis, fatigue, malaise, and headache 3 weeks after starting 100 mg daily dapsone for borderline-tuberculoid leprosy.
    • A 15-year-old male exhibited similar symptoms 9 days after initiating 50 mg daily dapsone for suspected indeterminate leprosy.

    Findings:

    • Both patients presented with drug-induced methemoglobinemia.
    • Discontinuation of dapsone led to the reversal of methemoglobinemia in both cases.

    Implications:

    • This highlights the potential risk of methemoglobinemia with dapsone therapy.
    • Clinicians should be vigilant for methemoglobinemia symptoms in patients treated with dapsone.
    • Early recognition and dapsone withdrawal are crucial for managing this adverse effect.