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Efficacy of Dapsone in Lichen Planus
Indian Journal of Dermatology, Venereology and Leprology
|January 28, 2017
Summary
Oral dapsone effectively treated adult patients, achieving complete healing in over 66% of cases within 16 weeks. This safe and well-tolerated treatment showed no relapses after a year, indicating its potential for long-term oral lichen planus management.
Area of Science:
- Dermatology
- Oral Medicine
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- Current treatments for OLP have limitations, necessitating exploration of alternative therapies.
Purpose of the Study:
- To evaluate the efficacy and safety of oral dapsone in treating adult patients with oral lichen planus.
Main Methods:
- A study involving 52 adult patients with OLP.
- Treatment consisted of oral dapsone 200 mg daily for 16 weeks.
- Concomitant topical or systemic medications were prohibited.
Main Results:
- 33 patients completed the 16-week study.
- Complete healing with hyperpigmentation occurred in 66.5% of patients.
- Partial response was observed in 21.5%, with 12% treatment failures.
- Patients with mucosal lesions showed earlier and more frequent response (80.0%).
- No relapses were reported during a one-year follow-up period.
Conclusions:
- Oral dapsone is a safe and effective treatment for oral lichen planus.
- High rates of complete healing and sustained remission were observed.
- Dapsone demonstrates significant potential for managing OLP, especially mucosal lesions.
