Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

706
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
706
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

870
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
870
Fibril-associated Collagen01:11

Fibril-associated Collagen

3.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.5K
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

690
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
690
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

3.2K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
3.2K
Reticular Dermis01:15

Reticular Dermis

5.3K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial Benign Chronic Pemphigus of Hailey and Hailey.

Indian journal of dermatology and venereology·2017
Same author

The De-Sanctis Cacchione Syndrome.

Indian journal of dermatology and venereology·2017
Same author

Thermo-stimulator a Device To Investigate Cases of Physical Urticaria.

Indian journal of dermatology and venereology·2017
Same author

Antioxidant status and lipid peroxidation in premenstrual syndrome: a preliminary study.

Clinica chimica acta; international journal of clinical chemistry·2001
Same author

Nose sign of exfoliative dermatitis: a possible mechanism.

Archives of dermatology·1992
Same author

Role of topical phenytoin in trophic ulcers of leprosy in India.

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·1991

Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models
04:42

Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

Published on: March 21, 2025

1.4K

Reactive Perforating Collagenosis.

G Kalia, Y K Malhotra, McR Vyas

    Indian Journal of Dermatology, Venereology and Leprology
    |January 28, 2017
    PubMed
    Summary

    Two brothers presented with asymptomatic, umbilicated papules since infancy, a condition diagnosed as reactive perforating collagenosis. Lesions showed Koebner phenomenon and healed with scarring, with no associated systemic diseases found.

    Area of Science:

    • Dermatology
    • Histopathology
    • Genetics

    Background:

    • Reactive perforating collagenosis (RPC) is a rare genodermatosis characterized by transepidermal elimination of dermal components.
    • RPC typically presents in childhood with pruritic papules that evolve into vesicles or pustules, often exacerbated by trauma.
    • Understanding the pathogenesis of RPC is crucial for effective management and genetic counseling.

    Observation:

    • Two brothers, aged 9 and 7 years, exhibited asymptomatic, umbilicated papules on extremities, buttocks, and the hairline since infancy.
    • Lesions demonstrated spontaneous healing with atrophic scarring, with new lesions appearing, particularly after trauma, indicating a Koebner phenomenon.
    • No underlying systemic conditions such as diabetes, renal, or hepatic disease were identified in either patient.

    Findings:

    More Related Videos

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
    04:37

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

    Published on: May 23, 2025

    1.2K
    Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
    06:07

    Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network

    Published on: October 17, 2025

    406

    Related Experiment Videos

    Last Updated: Mar 8, 2026

    Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models
    04:42

    Author Spotlight: Analyzing Fibrosis Development in Chronic Lung Allograft Rejection Using Picrosirius Red Staining in Mouse Models

    Published on: March 21, 2025

    1.4K
    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
    04:37

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

    Published on: May 23, 2025

    1.2K
    Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
    06:07

    Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network

    Published on: October 17, 2025

    406
    • Histopathological examination, including Van-Geison's stain, confirmed the diagnosis of reactive perforating collagenosis.
    • The clinical presentation and histopathological findings were consistent with a diagnosis of RPC.
    • The absence of systemic comorbidities suggests a primary cutaneous manifestation.

    Implications:

    • This case highlights the importance of recognizing RPC, even in its asymptomatic and atypical presentations.
    • Early diagnosis and management can potentially mitigate disease progression and improve quality of life.
    • Further research into the genetic underpinnings of RPC may lead to targeted therapies.