Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.4K
The Retina01:32

The Retina

78.1K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
78.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.5K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

11.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Basophil Activation Test Provides Additional Diagnostic Value Beyond Ara h 2-Specific IgE Testing in Peanut Allergic Adults.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Pseudoxanthoma Elasticum: The Diagnostic Accuracy of Genetic Testing Compared with Clinical Criteria in a Large Cohort.

The Journal of investigative dermatology·2025
Same author

Quality of life and participation after corneal transplantation and potential predictors: A multicenter prospective cohort study.

Acta ophthalmologica·2025
Same author

The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies.

Scientific reports·2025
Same author

Corrigendum: Therapeutic drug monitoring of anti-thymocyte globulin in allogeneic stem cell transplantation: proof of concept.

Frontiers in pharmacology·2024
Same author

Contact lenses in paediatric aphakia in the Netherlands; A multicentre retrospective chart study.

Contact lens & anterior eye : the journal of the British Contact Lens Association·2024
Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026
Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026
Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026
Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026
Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K

An Ocular Protein Triad Can Classify Four Complex Retinal Diseases.

J J W Kuiper1,2, L Beretta3, S Nierkens1

  • 1Laboratory of Translational Immunology, department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Scientific Reports
|January 28, 2017
PubMed
Summary
This summary is machine-generated.

A new molecular test using three proteins can accurately classify four major retinal diseases, aiding ophthalmologists in diagnosis. This approach offers a potential diagnostic aid for vision-threatening retinal conditions.

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.5K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.6K

Related Experiment Videos

Last Updated: Mar 8, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.5K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.6K

Area of Science:

  • Ophthalmology
  • Molecular Diagnostics
  • Biomarker Discovery

Background:

  • Retinal diseases are significant causes of vision loss.
  • Current diagnosis relies heavily on specialized clinical screening.
  • Need for improved diagnostic tools in ophthalmology.

Purpose of the Study:

  • To identify biomarkers for classifying four key retinal diseases using a single test.
  • To develop a molecular profiling approach for ocular conditions.
  • To assess the diagnostic potential of protein biomarkers in ocular fluids.

Main Methods:

  • Analysis of proteins in 175 ocular fluid samples.
  • Application of unsupervised clustering for disease classification.
  • Development and validation of a predictive model using specific protein levels.

Main Results:

  • Unsupervised clustering of proteins mirrored clinical disease phenotypes.
  • A model using Interleukin-10 (IL-10), Interleukin-21 (IL-21), and Angiotensin Converting Enzyme (ACE) was developed.
  • The model achieved 86.7% overall accuracy, 79.4% sensitivity, and 92.5% specificity.

Conclusions:

  • Molecular profiling of ocular fluids can aid in diagnosing retinal diseases.
  • A three-protein model demonstrates high accuracy in classifying specific retinal conditions.
  • This study provides proof-of-concept for a novel diagnostic aid in ophthalmology.