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Updated: Aug 13, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

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Published on: December 20, 2011

Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical

Maria Fitzgerald1, Catherine Millard, Neil McIntosh

  • 1Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT U.K. Department of Child Health, St. George's Hospital, London SW17 0QT U.K.

Pain
|October 1, 1989
PubMed

The flexion reflex threshold has been used as a measure of sensation in a group of premature infants born at 27-32 weeks postmenstrual age. The threshold in an area of local tissue damage created by routine heel lances was half the threshold on the intact heel on the other side. This indicated a hypersensitivity to tissue damage analogous to tenderness or hyperalgesia reported in adults. In a double-blind study, treatment of the damaged area with the topical anaesthetic cream, EMLA, was found to reverse this hypersensitivity or in other words increase the flexion reflex threshold. Treatment with placebo had no effect. The results show that the newborn infant central nervous system is capable of mounting a chronic pain response to local injury which can be reduced by local anaesthetic.

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