Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Protists II01:27

Diversity of Protists II

1.7K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
1.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.4K
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

661
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
661
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.7K
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

3.0K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<b>Unveiling Caribbean diversity: 11 new species of <i>Venezillo</i> Verhoeff, 1928 (Isopoda: Armadillidae) from Colombia and redescription of the type species</b>.

Zootaxa·2026
Same author

Corrigendum to "Borderline ovarian tumors and low-grade serous carcinoma: A retrospective analysis from argentine and Uruguayan oncology centers" [Surg. Oncology 66 (2026) 102441].

Surgical oncology·2026
Same author

Borderline ovarian tumors and low-grade serous carcinoma: A retrospective analysis from argentine and Uruguayan oncology centers.

Surgical oncology·2026
Same author

Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane.

International journal of medical microbiology : IJMM·2023
Same author

Peptide-pulsed dendritic cells' immunomodulating effect regarding Mycobacterium tuberculosis growth in macrophages.

Immunobiology·2023
Same author

Ecomorphology and Morphological Disparity of Caquetaia Kraussii (Perciformes: Cichlidae) in Colombia.

Animals : an open access journal from MDPI·2022

Related Experiment Video

Updated: Mar 8, 2026

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry
07:16

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry

Published on: April 5, 2015

10.5K

Functionally relevant proteins in Plasmodium falciparum host cell invasion.

Manuel E Patarroyo1,2, Martha P Alba1,3, Rocío Rojas-Luna1

  • 1Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20 Bogotá, Colombia.

Immunotherapy
|January 28, 2017
PubMed
Summary

Developing an effective malaria vaccine requires targeting sporozoite and merozoite proteins. Conserved peptides in these proteins are key targets for blocking parasite invasion and function.

Keywords:
cHABPinvasion-proteinsmalariamerozoitesporozoitevaccine

More Related Videos

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.9K
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
10:09

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Published on: January 3, 2012

19.6K

Related Experiment Videos

Last Updated: Mar 8, 2026

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry
07:16

In Vivo Assessment of Rodent Plasmodium Parasitemia and Merozoite Invasion by Flow Cytometry

Published on: April 5, 2015

10.5K
Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.9K
Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
10:09

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Published on: January 3, 2012

19.6K

Area of Science:

  • Malariology
  • Vaccinology
  • Molecular Biology

Background:

  • An effective malaria vaccine requires blocking parasite invasion at both the sporozoite and merozoite stages.
  • Proteins crucial for parasite survival and host cell invasion are prime targets for vaccine development.

Purpose of the Study:

  • To examine critical parasite proteins involved in host cell invasion.
  • To identify conserved amino acid sequences within these proteins as potential vaccine targets.

Main Methods:

  • Analysis of protein sequences involved in sporozoite invasion of hepatocytes.
  • Analysis of protein sequences involved in merozoite invasion of red blood cells.
  • Identification of conserved, high-activity binding peptides within strategic functional sites.

Main Results:

  • Identified conserved amino acid sequences in key sporozoite and merozoite proteins.
  • Located conserved peptides in functionally strategic sites related to binding, transport, and enzymatic activity.
  • These peptides demonstrate high binding activity.

Conclusions:

  • Conserved peptides in critical parasite proteins are excellent targets for antimalarial vaccine development.
  • Targeting these peptides can block essential protein-binding functions required for parasite invasion.
  • Vaccine strategies can leverage these peptides to inhibit parasite survival and function.