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Design of a Bioabsorbable Multilayered Patch for Esophagus Tissue Engineering.

Rossella Dorati1, Antonella De Trizio1, Stefania Marconi2

  • 1Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.

Macromolecular Bioscience
|January 28, 2017
PubMed
Summary

This study developed multilayered polymer patches for esophagus reconstruction. The 2-layer (2L) patches show promising stability and mechanical properties for esophageal tissue repair.

Keywords:
biopolymerschitosanpolylactide-co-polycaprolactonescaffoldtissue regeneration

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Esophageal reconstruction lacks a definitive gold standard treatment.
  • Development of functional tissue-engineered patches is crucial for esophageal repair.

Purpose of the Study:

  • To design and characterize multilayered polymer patches for esophagus reconstruction.
  • To tailor patch properties using polylactide-co-polycaprolactone and chitosan biopolymers.
  • To evaluate patch performance under simulated physiological and pathological conditions.

Main Methods:

  • Fabrication of multilayered patches (1L, 2L, 3L) using a temperature-induced precipitation method.
  • Characterization of patch stability, molecular weight (Mw), and mechanical properties (pressure, elongation).
  • In vitro assessment of cell adhesion and proliferation on patch surfaces.

Main Results:

  • Stable 1-layer (1L) and 2-layer (2L) patches were successfully fabricated by selecting copolymer type and Mw.
  • The 3-layer (3L) patch, incorporating chitosan, exhibited reduced stability and cell adhesion but enhanced cell proliferation.
  • 2L and 3L patches met physiological esophageal pressure (3-5 kPa) and elongation (20%) requirements.

Conclusions:

  • Multilayered polymer patches combining synthetic and natural polymers show potential for esophagus reconstruction.
  • The 2L patch offers a balance of stability and mechanical integrity suitable for esophageal applications.
  • Further optimization is needed to balance the effects of chitosan on patch properties and cellular interactions.