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[Clinico-endoscopic characteristics of gastroduodenal Campylobacter infection in children]
Insights
Campylobacter pylori (C. P.) infection is common in children, found in 50% of those studied. The screening-urease test alone is insufficient for diagnosing pyloric campylobacteriosis in pediatric patients.
Area of Science:
- Pediatric Gastroenterology
- Microbiology
- Infectious Diseases
Context:
- Esophagogastroduodenoscopy is a common diagnostic procedure in children.
- Campylobacter pylori (C. P.) is a significant pathogen in pediatric gastrointestinal disorders.
- Accurate diagnosis of C. P. infection is crucial for effective treatment.
Purpose:
- To investigate the prevalence of Campylobacter pylori (C. P.) in children undergoing esophagogastroduodenoscopy.
- To evaluate the diagnostic accuracy of microscopy, urease testing, and culture for C. P. detection.
- To identify clinical and endoscopic indicators associated with C. P. infection in children.
Summary:
- A study of 104 children (6 months-14 years) found C. P. in 50% via gastric and duodenal biopsies.
- C. P. was detected in 9 of 12 children with duodenal ulcer disease.
- Infection rates increased with longer gastroenterologic history; clinical signs were associated with C. P. presence.
Impact:
- Establishes the high prevalence of C. P. in symptomatic children.
- Highlights the limitations of the screening-urease test for definitive diagnosis.
- Informs clinical practice regarding C. P. diagnosis and management in pediatric populations.
Abstract:
During diagnostic esophagogastroduodenoscopy, 104 children aged 6 months to 14 years were subjected to spot biopsy of the mucous membrane of the antral part of the stomach and duodenal bulb with a purpose of subsequent studies for Campylobacter pyloris (C. P.) including primary microscopy, the screening-urease test and culture isolation followed by its identification according to all the necessary biochemical tests. C. P. were detected in 50% of the children examined including 9 out of 12 patients suffering from ulcer disease of the duodenum. It was shown that the C. P. incidence noticeably rose with an increase of the period of the gastroenterologic anamnesis. The characteristic clinical and endoscopic signs of the illness were defined, associated with most or less probable C. P. isolation. It has been established that the findings of the screening-urease test cannot form the basis for the final diagnosis of pyloric campylobacteriosis in children.