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Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Glasgow prognostic score is a prognosis predictor for patients with endometrial cancer
Masayuki Saijo1, Keiichiro Nakamura1, Hisashi Masuyama1
1Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Objective:
This study investigated whether the inflammation-based Glasgow prognostic score (GPS) predicted the prognosis of patients with endometrial cancer (EC) in terms of progression-free survival (PFS) and overall survival (OS).
Study Design:
Pretreatment GPS was examined to determine the correlations with recurrence and survival in 431 patients with EC. Statistical analyses were performed using the Mann-Whitney U test. PFS and OS were analyzed using the Kaplan-Meier method. Cox's proportional hazard regression was used for univariate and multivariate analyses.
Results:
Median PFS and OS were 49.7 and 52.7 months, respectively. The follow-up range was 1 to 140 months. Kaplan-Meier analysis revealed that patients with EC cancer and high GPS (GPS 2) had a shorter PFS and OS than those with lower GPS (GPS 0+1) (PFS: P<0.001; OS; P<0.001). On multivariate analysis, GPS (GPS 2) was an independent predictor of both recurrence (P<0.001) and survival (P<0.001) for all cases of EC.
Conclusion:
GPS can be useful as an indicator of poor prognosis in patients with EC.
