Related Experiment Video
Updated: Aug 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Alopecia areata and bisalbuminaemia (a casual coincidence)
Abstract:
Bisalbuminaemia, the heterozygote manifestation of an autosomal dominant condition, is detected by electrophoresis, when two distinct albumin bands are separated. Approximately 50 cases with bisalbuminaemia have been published worldwide. This phenomenon is very rare in Central Europe. A 17-year-old Hungarian girl, admitted for an alopecia areata of bacterial origin (tonsillitis), was found after routine electrophoresis to have bisalmbuminaemia. The albumin variant was of the "slow type". The ratio of the two components was 1:1. Immunoelectrophoresis with anti-albumin serum showed only one precipitation band in the albumin region. The rarity of bisalbuminaemia appeared to justify publication.
Related Concept Videos
Epistasis
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...

