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Related Experiment Video

Updated: Mar 8, 2026

Microgavage of Zebrafish Larvae
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Microgavage of Zebrafish Larvae

Published on: February 20, 2013

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Modeling intestinal disorders using zebrafish.

X Zhao1, M Pack1

  • 1University of Pennsylvania, Philadelphia, PA, United States.

Methods in Cell Biology
|January 29, 2017
PubMed
Summary
This summary is machine-generated.

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Zebrafish are increasingly used to study human intestinal diseases due to conserved biology. This model offers insights into congenital disorders, inflammation, and cancer, aiding gene discovery.

Area of Science:

  • Comparative biology
  • Gastroenterology
  • Developmental biology

Background:

  • Zebrafish (Danio rerio) initially a model for embryonic development.
  • Increasingly utilized for studying human diseases, particularly intestinal disorders.
  • Zebrafish digestive system is fully functional and visible by 5 days post fertilization.

Purpose of the Study:

  • Overview of zebrafish studies relevant to human intestinal disease.
  • Highlighting zebrafish utility in functional gene validation.
  • Discussing zebrafish-specific methodologies for intestinal biology.

Main Methods:

  • Review of studies on zebrafish intestinal development and physiology.
  • Focus on congenital disorders, host-microbiota interactions, inflammatory diseases, motility disorders, and intestinal cancer.
Keywords:
Enteric nervous systemGut motilityHost–microbe interactionsInflammatory bowel diseaseIntestinal epithelial cellMicrobiota

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  • Utilizing zebrafish for functional validation of candidate genes from genetic studies.

    • Main Results:

    • Demonstrated homology in cellular composition and function between zebrafish and vertebrate intestines.
    • Highlighted conserved molecular pathways for injury and immune responses.
    • Showcased zebrafish as a model for diverse intestinal conditions.

    Conclusions:

    • Zebrafish serve as a valuable model for investigating human intestinal diseases.
    • The conserved nature of intestinal biology in zebrafish aids in understanding disease mechanisms.
    • Zebrafish facilitate functional gene validation and exploration of intestinal biology.