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Related Concept Videos

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

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Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
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Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
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Sub-cellular localization specific SUMOylation in the heart.

Nhat-Tu Le1, James F Martin2, Keigi Fujiwara1

  • 1Department of Cardiology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|January 29, 2017
PubMed
Summary
This summary is machine-generated.

SUMOylation regulates cardiomyocyte function differently in nuclear and extra-nuclear compartments. Shuttling of SUMO proteases between compartments controls SUMOylation extent, impacting cardiac response to injury.

Keywords:
AMPKDRP-1ERK5HDACsNEMOPKCαPPARsPotassium channelSENP2SERCA2aSUMOylationUbc9XBP-1p90RSK

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • SUMOylation (Small Ubiquitin-like Modifier) is a post-translational modification.
  • While often nuclear, SUMOylation occurs in extra-nuclear compartments, affecting protein function.
  • Its role in cardiac health and disease is complex and compartment-dependent.

Purpose of the Study:

  • To review SUMOylation's role in different cellular compartments within cardiomyocytes.
  • To discuss SUMOylation's impact on cardiac function, both protective and detrimental.
  • To propose a novel concept regarding SUMO protease shuttling and its effect on cardiac insults.

Main Methods:

  • Review of existing literature on SUMOylation in cellular compartments.
  • Analysis of SUMOylation's effects on nuclear and extra-nuclear proteins in cardiomyocytes.
  • Discussion of the proposed mechanism of SUMO protease shuttling.

Main Results:

  • Extra-nuclear SUMOylation in cardiomyocytes is largely cardio-protective.
  • Nuclear SUMOylation often impairs cardiac function due to trans-repression of transcription factors.
  • SUMOylation may play a role in epigenetic regulation.

Conclusions:

  • SUMO protease shuttling between nuclear and extra-nuclear compartments is proposed as a key regulator of SUMOylation.
  • This shuttling influences cardiomyocyte fate after cardiac insults.
  • Targeting SUMO protease shuttling may offer therapeutic strategies for cardiac diseases.