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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Susceptibility to chronic inflammation: an update.

Noha Ahmed Nasef1, Sunali Mehta2,3,4, Lynnette R Ferguson5

  • 1Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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|January 29, 2017
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Summary

This review explores genetic and environmental factors contributing to chronic inflammation, a key driver of autoimmune and chronic diseases. Understanding these susceptibilities offers new therapeutic targets for disease prevention and treatment.

Keywords:
Chronic inflammationCytokinesDietImmunityInfectionStress

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Area of Science:

  • Immunology
  • Genetics
  • Environmental Health

Background:

  • Chronic inflammation, characterized by persistent inflammatory processes leading to tissue destruction, is central to many chronic diseases, including autoimmune conditions.
  • It significantly impacts disease progression and presents a complex challenge in medical research and treatment.

Purpose of the Study:

  • To review the latest research on genetic and environmental factors influencing chronic inflammation.
  • To provide an overview of current understanding and identify potential new therapeutic targets for chronic inflammatory and autoimmune diseases.

Main Methods:

  • Literature review focusing on recent advancements in cytokine research, gene identification (canonical and non-canonical), and the impact of infection, diet, and stress.
  • Synthesis of current evidence on genetic and environmental susceptibilities to chronic inflammation.

Main Results:

  • Updates in cytokine research and emerging treatments for chronic inflammation.
  • Identification of novel canonical and non-canonical genes associated with chronic inflammation.
  • Evidence highlighting the roles of infection, diet, and stress in promoting inflammation.

Conclusions:

  • Chronic inflammation is a complex condition influenced by intricate genetic and environmental interactions.
  • Further research into these factors can lead to the development of novel therapies to manage chronic inflammation and prevent disease progression.