Related Experiment Video

Updated: Mar 8, 2026

Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR
08:56

Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR

Published on: June 27, 2017

8.4K

MicroRNA-29: A Crucial Player in Fibrotic Disease

Zhenjun Deng1, Yongjing He1,2, Xujuan Yang1

  • 1Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.

Molecular Diagnosis & Therapy
|January 29, 2017
PubMed

Insights

MicroRNA-29 (miR-29) is crucial in regulating fibrotic diseases like cardiac and liver fibrosis. This review details miR-29

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Pathology

Background:

  • Fibrosis involves excessive extracellular matrix accumulation, with unclear pathogenesis.
  • MicroRNA-29 (miR-29) has been implicated in regulating various organ fibrotic conditions.
  • Understanding miR-29's role is key to addressing fibrotic diseases.

Purpose of the Study:

  • To review the structure, expression, and regulation of miR-29.
  • To elucidate the role of miR-29 in diverse fibrotic diseases.
  • To provide a comprehensive overview of miR-29 in fibrosis.

Main Methods:

  • Literature review of existing studies on miR-29 and fibrosis.
  • Analysis of miR-29 structure, expression patterns, and regulatory mechanisms.
  • Synthesis of data on miR-29's involvement in cardiac, hepatic, lung, and skin fibrosis.

Main Results:

  • miR-29 exhibits specific expression and regulatory patterns relevant to fibrosis.
  • Evidence supports miR-29's pivotal role in multiple organ fibrotic processes.
  • Dysregulation of miR-29 is linked to the pathogenesis of fibrotic conditions.

Conclusions:

  • miR-29 is a significant regulator in the pathogenesis of various fibrotic diseases.
  • Further research into miR-29 mechanisms could lead to novel therapeutic strategies.
  • Targeting miR-29 may offer a potential approach for treating fibrosis.

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.4K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K