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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Premenopausal Osteoporosis.

Adi Cohen1

  • 1Division of Endocrinology, Department of Medicine, Columbia University Medical Center, Columbia University, College of Physicians & Surgeons, PH8-864, 630 West 168th Street, New York, NY 10032, USA.

Endocrinology and Metabolism Clinics of North America
|January 30, 2017
PubMed
Summary
This summary is machine-generated.

Most premenopausal women with osteoporosis have an underlying cause. Identifying and treating the root cause is key, though some may need medication like bisphosphonates or teriparatide for bone density improvement.

Keywords:
Osteoporosis treatmentPremenopausal womenSecondary causes of osteoporosis

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Osteoporosis Research

Background:

  • Secondary causes are common in premenopausal women with osteoporosis or low bone mineral density.
  • Low trauma fractures in premenopausal women warrant investigation for underlying conditions.

Purpose of the Study:

  • To review the management of osteoporosis in premenopausal women.
  • To evaluate the role of pharmacologic interventions in specific cases.

Main Methods:

  • Literature review of clinical trials.
  • Analysis of evidence for bisphosphonates and teriparatide in premenopausal osteoporosis.

Main Results:

  • Bisphosphonates and teriparatide show benefits for bone mineral density in premenopausal osteoporosis.
  • Current studies are limited in size and do not confirm fracture risk reduction.

Conclusions:

  • Management should prioritize treating secondary causes of bone loss.
  • Pharmacologic options may be considered for persistent bone loss or fractures, but evidence for fracture reduction is lacking.