Retrospective comparative analysis of cardiovascular implantable electronic device infections with and without the

Related Experiment Video

Updated: Mar 8, 2026

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
07:50

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

Published on: January 7, 2019

7.4K

A Hassoun1, E D Thottacherry1, M Raja1

  • 1Department of Infectious Disease, Alabama Infectious Diseases Center, Huntsville, AL, USA.

The Journal of Hospital Infection
|January 30, 2017
PubMed
Abstract

Insights

Cardiovascular implantable electronic device (CIED) infections are a serious concern. The AIGISRx envelope did not reduce CIED infections and was associated with higher infection and mortality rates in this study.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomaterials

Background:

  • Cardiovascular implantable electronic device (CIED) infections pose significant risks.
  • Systemic antibiotic prophylaxis is standard for reducing CIED infections.
  • AIGISRx is a novel antibiotic-eluting envelope designed to prevent CIED infections.

Purpose of the Study:

  • To evaluate the efficacy of the AIGISRx envelope in preventing CIED infections.
  • To compare infection rates, implantation success, and mortality between patients with and without the AIGISRx envelope.

Main Methods:

  • A retrospective review of 184 patients undergoing CIED implantation.
  • Comparison of 92 patients with AIGISRx (AIGISRx group) versus 92 patients without (control group).
  • Analysis of demographics, risk factors, implantation success, infection rates, and mortality.

Main Results:

  • Both groups had a 97% successful implantation rate.
  • The AIGISRx group experienced significantly higher rates of major infection (5.4% vs 1.1%) and longer hospitalizations.
  • The AIGISRx group also showed higher rates of device replacement/revision and mortality.

Conclusions:

  • The AIGISRx envelope was associated with increased rates of major infection and mortality.
  • Patients receiving AIGISRx had more complex procedures and higher pre-existing risk factors.
  • Further investigation is needed to understand the role of AIGISRx in CIED infection prevention.
Keywords:
Cardiac implantable deviceComplicationsInfection

More Related Videos

A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess03:44

A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess

Published on: June 6, 2025

693
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.9K

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
42.4K
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
295
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
641
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.6K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.3K