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The synergistic effect of vascular cell adhesion molecule-1 and coronary artery disease on brain-derived neurotrophic

I-Te Lee1, Jun-Sing Wang2, Wen-Jane Lee3

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 30, 2017
PubMed

Insights

Coronary artery disease (CAD) is linked to lower brain-derived neurotrophic factor (BDNF) levels during glucose tests. Vascular cell adhesion molecule-1 (VCAM-1) exacerbates this effect in CAD patients.

Area of Science:

  • Neuroscience
  • Cardiology
  • Metabolic Health

Background:

  • Brain-derived neurotrophic factor (BDNF) plays a crucial role in neural protection and maintaining energy balance.
  • Vascular cell adhesion molecule-1 (VCAM-1) is implicated in vascular inflammation.
  • Coronary artery disease (CAD) is a significant cardiovascular condition.

Purpose of the Study:

  • To investigate the relationship between coronary artery disease (CAD) and serum levels of brain-derived neurotrophic factor (BDNF).
  • To examine the influence of vascular cell adhesion molecule-1 (VCAM-1) on BDNF levels in individuals with and without CAD.
  • To assess the impact of an oral glucose tolerance test (OGTT) on BDNF response in the context of CAD and VCAM-1 levels.

Main Methods:

  • Recruited 240 subjects (144 with CAD, 96 without) who underwent diagnostic angiography for angina.
  • Measured serum BDNF levels at 0, 30, and 120 minutes during an OGTT to calculate the area under the curve (AUC).
  • Assessed fasting serum VCAM-1 levels.

Main Results:

  • Subjects with CAD exhibited significantly lower BDNF AUC and higher serum VCAM-1 compared to controls.
  • Elevated VCAM-1 levels independently predicted lower BDNF AUC in both CAD and non-CAD groups.
  • CAD patients with high VCAM-1 displayed the lowest serum BDNF concentrations throughout the OGTT.

Conclusions:

  • Coronary artery disease is associated with a diminished BDNF response to oral glucose challenge.
  • VCAM-1 demonstrates a synergistic effect with CAD, further reducing BDNF levels.
  • These findings highlight a complex interplay between vascular health, inflammation, and neurotrophic factors in CAD.
Abstract

Keywords:
Brain-derived neurotrophic factorCoronary artery diseaseOral glucose tolerance testVascular cell adhesion molecule-1

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