Related Experiment Video

Updated: Mar 8, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.9K

High-Sensitivity Troponin Release Profile After Cardiac Surgery

Phuong L Markman1, John-Paul Tantiongco2, Jayme S Bennetts2

  • 1Flinders Medical Centre, Adelaide, SA, Australia.

Heart, Lung & Circulation
|January 30, 2017
PubMed

Insights

High sensitivity troponin T (hsTnT) release after cardiac surgery varies by procedure type. Peak hsTnT levels and timing correlate with the extent of myocardial injury, offering insights into surgical impact.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Biomarkers

Background:

  • Postoperative serum troponin levels and perioperative myocardial infarction (MI) rates are linked to mortality and morbidity after cardiac surgery.
  • Understanding troponin release profiles is crucial for assessing cardiac surgical outcomes.

Purpose of the Study:

  • To document the release profile of high sensitivity troponin T (hsTnT) following different cardiac surgical procedures.
  • To correlate hsTnT release patterns with surgical techniques and patient outcomes.

Main Methods:

  • Prospective recruitment of patients undergoing five distinct isolated cardiac surgical procedures.
  • Serial measurement of serum hsTnT at multiple time points (0-72 hours) post-surgery.
  • Inclusion criteria: preoperative hsTnT <29 ng/L and serum creatinine <0.2 mmol/L.

Main Results:

  • Peak hsTnT levels varied significantly across procedures, ranging from 64 ng/L (off-pump CAB) to 918 ng/L (mitral valve replacement).
  • Operations with lower peak hsTnT values peaked earlier (4 hours), while those with higher values peaked later (8 hours).
  • Five patients were excluded due to perioperative MI or renal failure.

Conclusions:

  • The hsTnT profile after cardiac surgery typically peaks 4-8 hours post-insult.
  • The magnitude and timing of peak hsTnT correlate with the degree of surgically-induced myocardial injury.
  • This provides a valuable biomarker profile for assessing cardiac surgical impact.
Abstract

Keywords:
Cardiac surgical proceduresHeart valve prosthesis implantationMyocardial revascularisationPerioperative periodTroponinTroponin T

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

17.2K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.8K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.0K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
355
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.3K
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
922
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
594
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
405