Related Experiment Video

Updated: Mar 8, 2026

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

6.3K

Attractors of hypertrophic cardiomyopathy using maximal cliques and attract methods

Ming-Jun Feng1, Hui-Min Chu1, Cai-Jie Shen2

  • 1Department of Cardiology, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China.

Computational Biology and Chemistry
|January 30, 2017
PubMed

Insights

This study identified key molecular pathways in hypertrophic cardiomyopathy (HCM). Proteasome, ribosome, and oxidative phosphorylation are implicated in HCM's pathophysiology, offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Cardiovascular Research

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex genetic heart disease.
  • Identifying molecular mechanisms underlying HCM is crucial for developing effective treatments.

Purpose of the Study:

  • To identify differential attractor modules associated with hypertrophic cardiomyopathy (HCM).
  • To integrate clustering-based maximal cliques algorithm and the Attract method for module discovery.

Main Methods:

  • Recruited HCM microarray data from ArrayExpress.
  • Constructed and re-weighted protein-protein interaction (PPI) networks for normal and HCM conditions using Spearman correlation coefficient (SCC).
  • Applied maximal cliques and Attract method to identify differential attractor modules, followed by pathway enrichment analysis.

Main Results:

  • Identified 926 and 1118 maximal cliques in normal and HCM PPI networks, respectively.
  • Obtained 32 and 55 modules from normal and HCM networks, identifying 5 differential attractor module pairs.
  • Pathway enrichment analysis revealed significant involvement of proteasome, ribosome, and oxidative phosphorylation pathways.

Conclusions:

  • Proteasome, ribosome, and oxidative phosphorylation pathways are significantly altered in HCM.
  • These pathways may play critical pathophysiological roles in the development of hypertrophic cardiomyopathy.
  • Findings provide insights into molecular mechanisms and potential therapeutic targets for HCM.
Abstract

Keywords:
AttractAttractor modulesHypertrophic cardiomyopathyModule correlation densityPathways

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

18.0K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
593
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
722
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
564
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
694
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
689