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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
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Right ventricular function during acute exacerbation of severe equine asthma
A Decloedt1, H Borowicz2, M Slowikowska2
1Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Equine Veterinary Journal
|January 30, 2017
Summary
Pulmonary hypertension in horses with severe equine asthma causes right ventricular changes. This study found structural and functional alterations in the right ventricle of asthmatic horses.
Area of Science:
- Equine cardiology
- Respiratory medicine
- Veterinary internal medicine
Background:
- Severe equine asthma is associated with pulmonary hypertension.
- The impact of pulmonary hypertension on the equine right ventricle is not fully understood.
Purpose of the Study:
- To assess right ventricular structure and function in horses experiencing pulmonary hypertension due to severe equine asthma exacerbation.
Main Methods:
- Experimental induction of severe equine asthma in six horses.
- Comprehensive assessments including echocardiography, pressure measurements, and myocardial biopsies.
- Comparison with ten healthy control horses.
Main Results:
- Significant increases in right heart pressures were observed.
- Echocardiography revealed altered right ventricular function and structure, including a thicker right ventricular wall.
- Asthmatic horses showed decreased right ventricular longitudinal strain even in remission.
Conclusions:
- Pulmonary obstruction in asthmatic horses leads to pulmonary hypertension.
- This induces measurable structural and functional changes in the right ventricle.
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