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Updated: Feb 7, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
[The key role of AMP-activated protein kinase (AMPK) in aging process]
Anna Michalik1, Robert Jarzyna1
1Department of Metabolic Regulation, Biochemistry Institute, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warszawa, Poland.
Abstract:
Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive. It appears that AMP - activated protein kinase (AMPK) plays an important role in many processes of aging, but this fact is often neglected in the studies on aging. This work summarizes the information about AMPK participation in the aging process. AMPK participation in the regulation of aging was indicated in the mechanisms dependent on: caloric restriction, mTOR, p53, sirtuins, autophagy, inflammation and the effects caused by polyphenols.
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