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Updated: Mar 8, 2026

Hybrid Clear/Blue Native Electrophoresis for the Separation and Analysis of Mitochondrial Respiratory Chain Supercomplexes
Published on: May 19, 2019
[Annexins in mitochondria]
Joanna Bandorowicz-Pikuła1, Marcin Woś1, Anna Sekrecka-Belniak1,2
1Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteura Street, 02-093 Warsaw, Poland.
Abstract:
Annexins form a family of membrane- and calcium-binding proteins, widely distributed in vertebrates. Their interactions with membranes are regulated by changes of intracellular concentration of calcium ([Ca2+]in.), pH, and the presence of negatively charged phospholipids as well as cholesterol in membranes. As protein participating in membrane fusion and sensors of a [Ca2+]in. Annexins may regulate various signaling pathways including patways involving protein kinase C (PKC isoforms. They also particpate in membrane repair mechanisms (along with actin cytoskeleton and S100 protein), in the vesicular transport (cholesterol enriched domains) as well in in intracellular calcium homeostasis and regulation of mitochondrial function and mitochondrial network structure. The last possibility is a topic of present review commemorating 90th Birthday of Professor Lech Wojtczak.
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