Related Experiment Video

Updated: Mar 8, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

33.6K

Interactions of CCAAT/enhancer-binding protein β with transcriptional coregulators

Maria Miller1

  • 1Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD, 21702-1201, USA.

Postepy Biochemii
|January 30, 2017
PubMed

Insights

CCAAT/enhancer-binding proteins (C/EBPs) regulate cell processes by forming protein complexes. C/EBPβ acts as a pioneering factor, interacting with chromatin to control gene expression.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Epigenetics

Background:

  • CCAAT/enhancer-binding proteins (C/EBPs) are crucial transcription factors regulating cell proliferation, differentiation, and tumorigenesis.
  • C/EBP family members (C/EBPα, β, δ, ε, and γ) form dimers to bind DNA and control eukaryotic gene transcription.
  • C/EBPβ is a pioneering factor that binds closed chromatin, initiating tissue-specific gene expression.

Purpose of the Study:

  • To review the intermolecular interactions governing C/EBPβ's function.
  • To highlight C/EBPβ's role in regulating chromatin accessibility.
  • To provide context on C/EBPβ's role in transcription regulation.

Main Methods:

  • Literature review of studies on C/EBPβ interactions.
  • Analysis of C/EBPβ's role as a pioneering transcription factor.
  • Focus on chromatin binding and gene regulation mechanisms.

Main Results:

  • C/EBPβ interactions are essential for its regulatory functions.
  • C/EBPβ facilitates chromatin opening for gene activation.
  • C/EBPβ participates in multiprotein complexes for DNA repair and cell cycle control.

Conclusions:

  • Intermolecular interactions are key to C/EBPβ's pioneering function.
  • C/EBPβ's ability to modify chromatin is central to its role in gene regulation.
  • Understanding these interactions provides insights into broader eukaryotic transcription regulation.
Keywords:
C/EBPβchromatin remodelingchromatin-modifying complexestranscription

More Related Videos

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.1K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.8K

Related Concept Videos

Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.8K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

3.2K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
11.2K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

4.1K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.5K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

2.7K