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Nylon microcapsules. II. Effect of selected variables on theophylline release
1Department of Pharmacy and Administrative Sciences, St. John's University, Jamaica, New York 11439.
Pharmaceutical Research
|August 1, 1989
Summary
Theophylline microcapsule release is influenced by preparation variables. Smaller particle size and slower sebacoyl chloride addition enhance theophylline release from microcapsules.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Microencapsulation is a key technique for controlled drug delivery.
- Theophylline is a widely used bronchodilator requiring controlled release formulations.
Purpose of the Study:
- To investigate how preparation variables affect theophylline release from microcapsules.
- To understand the impact of interfacial polycondensation parameters on microcapsule properties.
Main Methods:
- Preparation of theophylline microcapsules using interfacial polycondensation with 1,6-hexamethylene diamine and sebacoyl chloride.
- Systematic variation of organic phase type, particle size, stirring speed, and sebacoyl chloride addition rate.
- Analysis of microcapsule nature and theophylline release characteristics.
Main Results:
- Microcapsule properties and theophylline release were significantly affected by organic phase, particle size, stirring speed, and sebacoyl chloride addition rate.
- Lower stirring speeds reduced product aggregation.
- Decreased sebacoyl chloride addition rate increased aggregation and theophylline release.
- Smaller microcapsule particle size enhanced theophylline release.
Conclusions:
- Preparation parameters critically control theophylline microcapsule characteristics and drug release kinetics.
- Interfacial polycondensation offers tunable control over microcapsule properties for optimized theophylline delivery.
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