[Analysis of Treatment and Outcomes in Locally Advanced Breast Cancer]

Current treatment guidelines for locally advanced breast cancers recommend multimodality therapy consisting of chemotherapy followed by local treatment(surgery and radiotherapy). We retrospectively analyzed 35 cases oflocally advanced breast cancer at our institution between January 2004 and December 2014. Nine patients(25.7%)were treated with multimodality therapy consisting ofchemotherapy, surgery, and radiotherapy. Nineteen patients(54%)had disease recurrence and 9(26%)died. Factors that were significantly associated with recurrence were premenopausal, T1-3, and 4 or more lymph node metastases, and the number oflymph node metastases remained significant in the multivariable analysis. The median relapse-free survival was 1,147 days and the 5-year relapse-free survival rate was 49.7%. Survival rates were influenced by menopausal state and the number oflymph node metastases on the univariate analysis, but not in the multivariable analysis. Our results indicate that multimodality therapy is necessary particularly for patients with 4 or more lymph node metastases.