[Fourteen Cases of Low-Grade Appendiceal Mucinous Neoplasm]

Area of Science:

• Gastroenterology
• Surgical Oncology
• Pathology

Background:

• Low-grade appendiceal mucinous neoplasm (LAMN) is a rare gastrointestinal malignancy.
• LAMN classification aligns with the 2010 WHO Classification and Japanese Classification of Colorectal Carcinoma 8th edition.
• Accurate preoperative diagnosis can be challenging, with appendiceal mucocele being a common preoperative diagnosis.

Purpose of the Study:

• To evaluate the clinical characteristics, treatment, and outcomes of patients with LAMN.
• To assess the efficacy of surgical interventions for LAMN.
• To provide insights into the management strategy for LAMN.

Main Methods:

• Retrospective review of 14 patients diagnosed with LAMN over a 5-year period.
• Analysis of preoperative diagnoses, surgical interventions (ileocecal resection and appendectomy, including laparoscopic approaches), and histopathological findings.
• Evaluation of patient outcomes, including recurrence and survival rates, with or without adjuvant therapies.

Main Results:

• Preoperative diagnosis was appendiceal mucocele in 9 out of 14 cases.
• Surgical interventions included ileocecal resection (6 cases) and appendectomy (8 cases), with a significant number of laparoscopic procedures.
• No lymph node metastasis was observed histopathologically. All patients remained alive without recurrence, irrespective of adjuvant therapy administration.

Conclusions:

• LAMN is a rare appendiceal neoplasm with favorable outcomes following surgical resection.
• The established treatment strategy for LAMN is lacking; however, surgical intervention combined with vigilant postoperative surveillance appears effective.
• Further research is warranted to establish definitive treatment guidelines for LAMN.