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Gelatinous Marrow Transformation Associated with Imatinib: Case Report and Literature Review

E Chang1, G Rivero1, B Jiang2

  • 1Department of Hematology and Oncology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA; Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

Case Reports in Hematology
|January 31, 2017
PubMed

Gelatinous marrow transformation (GMT) is a rare condition observed in severe illness or malnutrition, in which the bone marrow contains amorphous "gelatinous" extracellular material, and histopathology demonstrates varied degrees of fat cell atrophy and loss of hematopoietic elements. An association of GMT with imatinib use in chronic myeloid leukemia (CML) has been reported recently. The objective of this study is to describe a case of GMT associated with imatinib use and review the existing similar cases in the literature to identify epidemiological patterns and potential imatinib-induced mechanisms leading to gelatinous conversion.

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