Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlation between mandibular/maxillary torus and periodontitis: a cross-sectional study.

Quintessence international (Berlin, Germany : 1985)·2026
Same author

Transplacental treatment of foetal ventricular tachycardia: a Japanese, nationwide survey.

European heart journal·2026
Same author

Clinical Outcomes of Fontan-Associated Hepatocellular Carcinoma: a Single-Center Retrospective Study.

Journal of gastroenterology and hepatology·2026
Same author

Tailored Ablation Strategies for Atrial Fibrillation With Common Inferior Pulmonary Vein Variants.

JACC. Case reports·2026
Same author

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Cardiology in the young·2025
Same author

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase.

Journal of visualized experiments : JoVE·2025

Related Experiment Video

Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K

Ca2+ dynamics in zebrafish morphogenesis.

Yusuke Tsuruwaka1, Eriko Shimada1,2,3, Kenta Tsutsui1

  • 1Marine Bioresource Exploration Research Group, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokosuka, Japan.

Peerj
|January 31, 2017
PubMed
Summary

Researchers visualized continuous intracellular calcium ion (Ca2+) patterns during zebrafish development for the first time using a novel Ca2+ sensor. This provides new insights into Ca2+ signaling during morphogenesis and differentiation.

Keywords:
Intracellular calciumYellow cameleonZebrafish

More Related Videos

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos
08:42

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos

Published on: February 19, 2016

8.5K
Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy
06:35

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy

Published on: September 30, 2013

13.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K
Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos
08:42

Immunostaining Phospho-epitopes in Ciliated Organs of Whole Mount Zebrafish Embryos

Published on: February 19, 2016

8.5K
Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy
06:35

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy

Published on: September 30, 2013

13.4K

Area of Science:

  • Developmental Biology
  • Cellular Signaling
  • Biophysics

Background:

  • Intracellular calcium ion (Ca2+) signaling plays a crucial role in embryonic development.
  • Previous studies have utilized Ca2+ indicators, but continuous patterns during morphogenesis remain understudied.
  • Fluorescence resonance energy transfer (FRET) offers a method to track Ca2+ sensor dynamics.

Purpose of the Study:

  • To monitor Ca2+ levels and patterns during zebrafish (Danio rerio) morphogenesis and differentiation.
  • To investigate continuous Ca2+ dynamics using the yellow cameleon (YC2.12) FRET-based Ca2+ sensor.
  • To establish novel findings in Ca2+ signaling research through advanced sensor technology.

Main Methods:

  • Utilized the yellow cameleon (YC2.12) FRET-based Ca2+ sensor.
  • Monitored Ca2+ levels and dynamics in zebrafish embryos during development.
  • Observed Ca2+ patterns from the late gastrula through segmentation and pharyngula periods (24-33 hpf).

Main Results:

  • Successfully visualized continuous Ca2+ patterns during zebrafish morphogenesis for the first time.
  • Observed clear changes in Ca2+ levels and dynamics from 24 hours post-fertilization (hpf) onwards.
  • Correlated high Ca2+ levels with hindbrain development during segmentation and pharyngula periods.
  • Validated Ca2+ patterns in earlier developmental stages (late gastrula to segmentation) against previous sensor data.

Conclusions:

  • The study provides the first observation of continuous Ca2+ patterns during zebrafish morphogenesis.
  • The yellow cameleon sensor enabled novel insights into Ca2+ dynamics during critical developmental periods.
  • Findings highlight the potential of advanced Ca2+ sensors for future discoveries in Ca2+ signaling research.