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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell...
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Mar 8, 2026

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
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MSC Therapeutics in Chronic Inflammation.

Alex Sargent1, Robert H Miller2

  • 1Department of Neurosciences, Case Western Reserve University, School of Medicine.

Current Stem Cell Reports
|January 31, 2017
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for treating chronic inflammatory diseases by modulating immune responses, not direct tissue repair. This cell therapy approach is being developed for conditions like rheumatoid arthritis and multiple sclerosis.

Keywords:
EAEImmune suppressionMesenchymal stem cellsMultiple Sclerosis

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, are increasingly used in cell-based therapies.
  • Understanding MSC biology is crucial for their therapeutic application.
  • Ongoing inflammatory damage characterizes many chronic diseases.

Purpose of the Study:

  • To discuss the principles linking chronic inflammatory conditions.
  • To explore the aspects of MSC biology relevant to treating chronic inflammation.
  • To highlight the potential of MSCs in managing inflammatory diseases.

Main Methods:

  • Review of pre-clinical and clinical studies on MSCs.
  • Analysis of MSCs' immunomodulatory and regenerative capacities.
  • Identification of common themes in MSC-based therapies for diverse inflammatory conditions.

Main Results:

  • MSCs primarily reduce disease burden by modulating host immune responses.
  • Direct tissue regeneration is not the main mechanism of MSC action.
  • MSC-based therapies are being developed for diverse conditions like rheumatoid arthritis and multiple sclerosis.

Conclusions:

  • MSCs possess significant potential for treating chronic inflammatory diseases across various tissues.
  • The immunomodulatory properties of MSCs are key to their therapeutic efficacy.
  • Further understanding of MSC biology will enhance their application in inflammatory disease management.