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Updated: Mar 8, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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The HIV-1 envelope glycoprotein structure: nailing down a moving target

Andrew B Ward1, Ian A Wilson1,2

  • 1Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative Neutralizing Antibody Center, Collaboration for AIDS Vaccine Discovery, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA, USA.

Immunological Reviews
|January 31, 2017
PubMed
Summary

High-resolution structures of the HIV-1 envelope glycoprotein (Env) reveal its complex glycan shield and plasticity. These insights enable the design of novel immunogens for developing effective HIV vaccines.

Keywords:
HIV envelope structurecryo-electron microscopyepitope mappingglycan shieldstructure-based vaccine designx-ray crystallography

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