Related Experiment Video
Updated: Mar 8, 2026

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
DNA-modified artificial viral capsids self-assembled from DNA-conjugated β-annulus peptide
Yoko Nakamura1, Saki Yamada1, Shoko Nishikawa1
1Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, 680-8552, Japan.
Abstract:
β-Annulus peptides from tomato bushy stunt virus conjugated with DNAs (dA20 and dT20 ) at the C-terminal were synthesized. The DNA-modified β-annulus peptides self-assembled into artificial viral capsids with sizes of 45-160 nm. ζ-Potential measurements revealed that the DNAs were coated on the surface of artificial viral capsids. Fluorescence assays indicated that the DNAs on the artificial viral capsids were partially hybridized with the complementary DNAs. Moreover, the DNA-modified artificial viral capsids formed aggregates by adding complementary polynucleotides. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
More Related Videos
Related Concept Videos
Viral Structure
Introduction to Virus
DNA Bacteriophages
Retrovirus Life Cycles
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Lytic Cycle of Bacteriophages

