Use of topical sirolimus in the management of multiple familial trichoepitheliomas
Related Experiment Video
Updated: Mar 8, 2026
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Joanna H Tu1,2, Joyce M C Teng2
1Columbia University College of Physicians and Surgeons, New York, New York.
Abstract:
The management of trichoepitheliomas is challenging, especially in children. This challenge is exemplified in patients with multiple trichoepitheliomas who present with progression of lesion count and size despite treatment with current strategies, including CO2 laser and surgery. We present the novel use of topical 1% sirolimus cream in two siblings with multiple facial trichoepitheliomas; one was treated with a combination of CO2 laser ablation and topical sirolimus, and the other was treated with topical sirolimus alone. Both siblings had a reduction in the growth of new lesions with no reported side effects. This is the first report demonstrating that topical sirolimus, either in combination with CO2 laser or alone, can be a promising treatment for trichoepitheliomas.
Insights
Topical sirolimus cream shows promise for treating multiple trichoepitheliomas, a challenging skin condition. This novel approach, used alone or with CO2 laser ablation, reduced lesion growth in pediatric patients without side effects.
Area of Science:
- Dermatology
- Oncology
Background:
- Trichoepitheliomas are benign skin tumors that can be challenging to manage, particularly in pediatric patients.
- Current treatments like CO2 laser ablation and surgery often have limited efficacy for multiple or progressing lesions.
Related Concept Videos
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:19Clinical Applications of Epidermal Stem Cells