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The effects of hydroporation on melasma with anti-aging cocktail

Je Byeong Chae1,2, Seung Hye Yang2, Sang Young Byun1,2

  • 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Journal of Cosmetic Dermatology
|January 31, 2017
PubMed
Abstract

Insights

Hydroporation using a GHR formulation significantly improved melasma by reducing pigmentation and erythema. This treatment also enhanced skin

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Skin Rejuvenation

Background:

  • Jet-M device utilizes air and microdroplets for epidermal peeling and substance delivery.
  • Previous case study showed significant improvement in aged skin with a specific GHR formulation.
  • The GHR formulation includes copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan.

Purpose of the Study:

  • To evaluate the efficacy of hydroporation with the GHR formulation for treating melasma.
  • Assessing the effects on pigmentation and erythema in a small group of volunteers.

Main Methods:

  • Clinical evaluation using subjective assessments.
  • Objective measurements including melanin index (MI) and erythema index (EI).
  • Histopathologic analysis to observe changes in dermal components and cellular activity.

Main Results:

  • Significant reduction in clinical pigmentation and erythema.
  • Decreased melanin index (MI) and erythema index (EI) measurements.
  • Histological evidence of increased type IV collagen and procollagen in the upper dermis.
  • Upregulation of p63-positive cells along the basement membrane, indicating enhanced cellular activity.

Conclusions:

  • Hydroporation with the GHR formulation demonstrates depigmenting and erythema-reducing effects.
  • The treatment promotes anti-aging effects through extracellular matrix reconstruction.
  • Improvements are attributed to the enhancement of the skin's microenvironment.
Keywords:
Jet-Mbasement membranecollagenhydroporationmelasma

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