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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Microbiome engineering: Current applications and its future.

Jee Loon Foo1,2, Hua Ling1,2, Yung Seng Lee2,3

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Biotechnology Journal
|January 31, 2017
PubMed
Summary
This summary is machine-generated.

Microbiome engineering modifies microbial communities to restore ecological balance, improving health and agriculture. This review covers applications, challenges, and future directions in microbiome engineering.

Keywords:
Agricultural productivityHuman healthMicrobiome engineeringMicrobiota

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Area of Science:

  • Microbiology
  • Ecology
  • Biotechnology

Background:

  • Microbiomes, comprising diverse microbial communities, are crucial for ecosystem and host health.
  • Perturbations in microbiomes can lead to diseases, disorders, and ecological imbalance.
  • Microbiome engineering offers a strategy to manipulate microbial communities.

Purpose of the Study:

  • To review the importance and applications of microbiome engineering.
  • To explore current uses in human health, animal husbandry, agriculture, and soil science.
  • To discuss challenges and future prospects in the field of microbiome engineering.

Main Methods:

  • Literature review of microbiome engineering.
  • Analysis of applications across various domains (human, animal, plant, soil).
  • Exploration of challenges and future trends.

Main Results:

  • Microbiome engineering is vital for restoring ecological balance and improving host phenotypes.
  • Key applications include enhancing human health and agricultural productivity.
  • The field presents significant challenges but holds promising future potential.

Conclusions:

  • Microbiome engineering is a powerful tool for addressing health and environmental issues.
  • Continued research is needed to overcome engineering challenges and unlock full potential.
  • The future of microbiome engineering involves innovative strategies for microbial community manipulation.