Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desmosomes01:05

Desmosomes

8.5K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
8.5K
Cells of the Epidermis01:24

Cells of the Epidermis

8.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
8.6K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.2K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K
Pedigree Analysis01:35

Pedigree Analysis

90.3K
Overview
90.3K
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

15.1K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
15.1K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PEGylated liposomes enhance the pharmacokinetics, biodistribution, anticancer efficacy, and safety of Kaempferol, a phytomolecule enrolled in clinical trials.

Scientific reports·2026
Same author

Bulk and surface engineered drug delivery system of repurposed drug enhances low-dose gemcitabine efficacy in pancreatic cancer.

International journal of pharmaceutics·2025
Same author

Optimizing medication therapy in elderly patients: The impact of medication review using STOPP and START criteria version 2.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2024
Same author

Pathophysiology-Driven Approaches for Overcoming Nanomedicine Resistance in Pancreatic Cancer.

Molecular pharmaceutics·2024
Same author

Health technology assessment for digital health Technologies in India: a framework for action.

International journal of technology assessment in health care·2024
Same author

Integrative management of insomnia during cancer chemotherapy: A case report.

Journal of Ayurveda and integrative medicine·2024

Related Experiment Video

Updated: Mar 8, 2026

Isolation of Mouse Epidermal Keratinocytes and Their In Vitro Clonogenic Culture
06:16

Isolation of Mouse Epidermal Keratinocytes and Their In Vitro Clonogenic Culture

Published on: August 10, 2019

19.0K

Hereditary Benign Intraepithelial Dyskeratosis.

K Pavithran

    Indian Journal of Dermatology, Venereology and Leprology
    |January 31, 2017
    PubMed
    Summary

    Hereditary benign intraepithelial dyskeratosis is a rare genetic disorder affecting oral and conjunctival tissues. This case study highlights its familial occurrence and characteristic histopathological findings in a young male patient.

    Area of Science:

    • Ophthalmology
    • Oral Medicine
    • Genetics

    Background:

    • Hereditary benign intraepithelial dyskeratosis is a rare genetic condition.
    • The condition presents with characteristic oral and conjunctival lesions.

    Observation:

    • A 21-year-old male presented with hereditary benign intraepithelial dyskeratosis.
    • His mother and younger brother were also diagnosed with the same condition.
    • All affected individuals exhibited oral and conjunctival lesions.

    Findings:

    • The histopathological examination revealed characteristic features consistent with the diagnosis.
    • The familial pattern suggests an autosomal dominant inheritance pattern.

    Implications:

    More Related Videos

    Generation and Culturing of Primary Human Keratinocytes from Adult Skin
    10:42

    Generation and Culturing of Primary Human Keratinocytes from Adult Skin

    Published on: December 22, 2017

    17.5K
    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
    05:44

    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

    Published on: June 10, 2025

    1.3K

    Related Experiment Videos

    Last Updated: Mar 8, 2026

    Isolation of Mouse Epidermal Keratinocytes and Their In Vitro Clonogenic Culture
    06:16

    Isolation of Mouse Epidermal Keratinocytes and Their In Vitro Clonogenic Culture

    Published on: August 10, 2019

    19.0K
    Generation and Culturing of Primary Human Keratinocytes from Adult Skin
    10:42

    Generation and Culturing of Primary Human Keratinocytes from Adult Skin

    Published on: December 22, 2017

    17.5K
    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
    05:44

    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

    Published on: June 10, 2025

    1.3K
  • Understanding the genetic basis of this condition is crucial for diagnosis and genetic counseling.
  • Further research into the molecular mechanisms can aid in developing targeted therapies.