Tab Vaccine Causing Erythema Multiforme

Area of Science:

• Immunology
• Dermatology
• Ophthalmology

Background:

• TAB vaccine, a combination typhoid-paratyphoid vaccine, is used for active immunization against Salmonella Typhi and Salmonella Paratyphi.
• Adverse drug reactions, though rare, can occur following vaccinations.

Observation:

• A family member who received TAB vaccination developed erythema multiforme.
• The condition progressed to Stevens Johnson syndrome (SJS), a severe mucocutaneous reaction.

Findings:

• The patient recovered from Stevens Johnson syndrome.
• Residual bilateral corneal opacities were noted post-recovery, impacting vision.

Implications:

• This case highlights a potential severe adverse reaction to TAB vaccination, emphasizing the need for vigilant monitoring.
• The occurrence of corneal opacities underscores the importance of ophthalmological evaluation after severe cutaneous drug reactions.