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Tab Vaccine Causing Erythema Multiforme.

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    A rare case of Stevens Johnson syndrome (SJS) with erythema multiforme developed in one family member after TAB vaccination. The patient experienced residual bilateral corneal opacities following recovery from SJS.

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    Area of Science:

    • Immunology
    • Dermatology
    • Ophthalmology

    Background:

    • TAB vaccine, a combination typhoid-paratyphoid vaccine, is used for active immunization against Salmonella Typhi and Salmonella Paratyphi.
    • Adverse drug reactions, though rare, can occur following vaccinations.

    Observation:

    • A family member who received TAB vaccination developed erythema multiforme.
    • The condition progressed to Stevens Johnson syndrome (SJS), a severe mucocutaneous reaction.

    Findings:

    • The patient recovered from Stevens Johnson syndrome.
    • Residual bilateral corneal opacities were noted post-recovery, impacting vision.

    Implications:

    • This case highlights a potential severe adverse reaction to TAB vaccination, emphasizing the need for vigilant monitoring.
    • The occurrence of corneal opacities underscores the importance of ophthalmological evaluation after severe cutaneous drug reactions.