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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Humoral Immuno-deficiency in Lichen Planus.

Pramod K Nigam, Gurmohan Singh, Lata Sharma

    Indian Journal of Dermatology, Venereology and Leprology
    |January 31, 2017
    PubMed
    Summary

    Idiopathic lichen planus patients showed significantly reduced immunoglobulin A (IgA) and immunoglobulin M (IgM) levels compared to healthy individuals. This suggests a potential humoral immunodeficiency in lichen planus.

    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Lichen planus is an inflammatory condition affecting skin and mucous membranes.
    • The role of humoral immunity in lichen planus pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate serum immunoglobulin levels in patients with idiopathic lichen planus.
    • To determine if reduced immunoglobulin levels correlate with disease characteristics.

    Main Methods:

    • Serum immunoglobulin G (IgG), IgA, and IgM levels were measured.
    • Levels were compared between 41 lichen planus patients and 25 healthy controls.
    • Association with mucosal involvement was analyzed.

    Main Results:

    • No significant difference in IgG levels was found between groups.

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  • Significantly reduced IgA and IgM levels were observed in lichen planus patients.
  • No association between reduced IgA/IgM and mucosal involvement was identified.

    • Conclusions:

    • Lichen planus patients may exhibit humoral immunodeficiency.
    • Further research is warranted to explore the implications of these findings.