Related Experiment Video
Updated: Mar 8, 2026
07:29
Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
Published on: May 16, 2020
6.8K
Porokeratosis (Report of five Cases)
Indian Journal of Dermatology, Venereology and Leprology
|January 31, 2017
Summary
This study reports five porokeratosis cases, including Mibelli and disseminated superficial types. Successful treatment was observed with short contact dithranol and isotretinoic acid in one patient.
Area of Science:
- Dermatology
- Histopathology
Background:
- Porokeratosis is a rare keratinization disorder.
- Clinical presentations vary, including Mibelli and disseminated superficial types.
Observation:
- Five distinct cases of porokeratosis were documented.
- Case variations included linear involvement and disseminated superficial lesions.
- Histopathological analysis confirmed typical features for Mibelli and disseminated superficial porokeratosis.
Findings:
- Two cases presented as classical porokeratosis of Mibelli.
- Linear porokeratosis was observed, ranging from segmental limb involvement to unilateral body-wide lesions.
- Disseminated superficial porokeratosis showed characteristic histopathological findings.
Implications:
- This case series expands the understanding of porokeratosis clinical diversity.
- Successful treatment with short contact dithranol and isotretinoic acid suggests potential therapeutic options.
- Further research into effective treatments for various porokeratosis subtypes is warranted.
Related Concept Videos
01:11Papillary Dermis
6.5K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.5K
01:19Clinical Applications of Epidermal Stem Cells
3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
01:24Cells of the Epidermis
8.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
8.6K
01:30Skin Cancer
6.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.4K