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PCP and conditioned place preferences.

S H Marglin1, W C Milano, M E Mattie

  • 1Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.

Pharmacology, Biochemistry, and Behavior
|June 1, 1989
PubMed
Summary
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Male rats developed a positive conditioned place preference (CPP) for phencyclidine (PCP) at a high dose, similar to morphine. This suggests PCP has reinforcing properties within a narrow dose range, despite potential aversive effects.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Phencyclidine (PCP) is a dissociative anesthetic with known psychotomimetic effects.
  • Understanding the reinforcing properties of PCP is crucial for addiction research.

Purpose of the Study:

  • To investigate the potential for phencyclidine (PCP) to establish a positive conditioned place preference (CPP) in rats.
  • To compare PCP's reinforcing effects with those of morphine.

Main Methods:

  • Male Sprague-Dawley rats were administered systemic injections of PCP (0.25, 0.35, 0.45 mg/kg) or morphine (4.0 mg/kg).
  • Conditioned place preference (CPP) testing was used to assess the rewarding effects of the drugs.
  • Control groups received saline injections.

Related Experiment Videos

Main Results:

  • Rats receiving 0.45 mg/kg PCP demonstrated a significant positive CPP.
  • Morphine administration also resulted in a positive CPP, serving as a positive control.
  • Previous studies indicated that higher PCP doses or longer post-administration times lead to aversion.

Conclusions:

  • A specific, higher dose of PCP (0.45 mg/kg) exhibits positively reinforcing properties in rats, as evidenced by CPP.
  • The emergence of PCP's reinforcing effects appears limited to a narrow dose range and timeframe.
  • These findings may relate to PCP's psychotomimetic potential and its capacity for self-administration despite aversive consequences.