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Cutaneous Reactions to Targeted Therapy

Jonathan J Lee1, Daniela Kroshinsky, Mai P Hoang

  • 1*Dermatology Resident, University of Pittsburg Medical Center, Pittsburg, PA; Associate Professor, Departments of †Pathology, and ‡Dermatology, Massachusetts General Hospital, Boston, MA; and §Associate Professor, Harvard Medical School, Boston, MA.

The American Journal of Dermatopathology
|January 31, 2017
PubMed

Insights

Targeted cancer therapies improve outcomes but frequently cause skin reactions. Dermatopathologists must recognize these diverse adverse cutaneous reactions to manage patient care effectively.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Targeted therapeutic agents have revolutionized cancer treatment, improving outcomes for solid and hematologic malignancies.
  • Adverse cutaneous reactions are common toxicities associated with these targeted agents.
  • Understanding these skin reactions is crucial for effective clinical management.

Purpose of the Study:

  • To highlight the importance of recognizing diverse adverse cutaneous reactions.
  • To inform dermatopathologists about the spectrum of skin toxicities from targeted cancer therapies.
  • To emphasize the need for awareness of mechanistically diverse targeted agents.

Main Methods:

  • Review of clinical data and literature on targeted cancer therapies.
  • Analysis of common and uncommon adverse cutaneous reaction patterns.
  • Correlation of specific agents with observed dermatologic toxicities.

Main Results:

  • Targeted agents, while beneficial, frequently induce a wide range of skin side effects.
  • These cutaneous reactions can significantly impact treatment plans and patient quality of life.
  • Recognizing specific patterns aids in diagnosis and management.

Conclusions:

  • Adverse cutaneous reactions are a significant clinical challenge in targeted cancer therapy.
  • Dermatopathologists play a key role in identifying and managing these toxicities.
  • Awareness of the diverse mechanisms of targeted agents is essential for dermatopathologists.

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