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Review: Receptor Targeted Nuclear Imaging of Breast Cancer

Simone U Dalm1, John Fred Verzijlbergen2, Marion De Jong3

  • 1Department of Radiology & Nuclear medicine, Erasmus MC, Wytemaweg 80, 3015CN Rotterdam, The Netherlands. s.dalm@erasmusmc.nl.

International Journal of Molecular Sciences
|January 31, 2017
PubMed

Insights

Nuclear imaging targets specific breast cancer (BC) cell markers for sensitive detection. Choosing the right radiotracer is crucial due to BC

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Molecular Imaging

Background:

  • Breast cancer (BC) imaging benefits from receptor-targeted nuclear imaging.
  • Key molecular targets include estrogen receptor (ER), progesterone receptor (PR), HER2, SSTR, and GRPR.
  • Target expression varies by BC subtype, influencing imaging information.

Purpose of the Study:

  • To provide an overview of current receptor-targeted nuclear imaging studies for BC.
  • To summarize findings from imaging studies.
  • To discuss the purposes of lesion visualization via molecular marker targeting.

Main Methods:

  • Review of current receptor-targeted nuclear imaging studies for breast cancer.
  • Summarization of imaging study findings.
  • Discussion of potential applications for lesion visualization.

Main Results:

  • Several molecular targets (ER, PR, HER2, SSTR, GRPR) are under investigation for BC imaging.
  • ER-targeting radiotracers can monitor response to anti-estrogen therapy.
  • Information gained from imaging depends on the targeted receptor.

Conclusions:

  • Receptor-targeted nuclear imaging is a sensitive and specific method for breast cancer detection.
  • Careful selection of radiotracers is essential due to BC heterogeneity and dynamic target expression.
  • Imaging strategies must consider BC subtype, disease progression, and treatment effects.
Keywords:
ERGRPRHER2PETPRSPECTSSTRbreast cancerreceptor targeted nuclear imaging

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