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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

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Bioactive Polymeric Materials for Tissue Repair.

Diane R Bienek¹, Wojtek Tutak^2,3, Drago Skrtic⁴

¹Volpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USA. diane.bienek@nist.gov.

Journal of Functional Biomaterials

|January 31, 2017

Summary

Bioactive amorphous calcium phosphate (ACP) polymeric composites enhance hard tissue repair by supporting mineral regeneration and resisting demineralization. Tailoring ACP dispersion and polymer properties optimizes ion release, mechanical strength, and remineralization efficacy.

Keywords:

airbrushing amorphous calcium phosphate blow spinning bone repair cell/fiber interactions nanofibers remineralizing polymeric composite

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Area of Science:

Biomaterials Science
Polymer Chemistry
Dental Materials

Background:

Bioactive polymeric materials based on calcium phosphates are crucial for hard tissue repair due to their biocompatibility.
Amorphous calcium phosphate (ACP) enhances hard tissue regeneration and prevents demineralization.
Research has focused on structure/composition/property relationships in ACP polymeric composites for two decades.

Purpose of the Study:

To investigate how ACP dispersion in polymer matrices and resin fine-tuning impact composite properties.
To analyze the influence of filler/resin interface and polymer structure on ion release and mechanical strength.
To evaluate the remineralization efficacy of ACP composites under acidic conditions and explore nanofiber scaffold fabrication.

Main Methods:

Dispersion of ACP within polymer matrices.
Fine-tuning of resin components and polymer molecular structure.
Assessment of physicochemical, mechanical, and biological properties.
Evaluation of ion release kinetics and remineralization under acidic challenges.
Fabrication of nanofiber scaffolds using airbrushing technology.

Main Results:

Optimized ACP dispersion and resin composition significantly affect composite properties.
The filler/resin interface and polymer structure critically influence ion release and mechanical strength.
ACP composites demonstrate remineralization efficacy against acidic challenges, mimicking oral environments.
Airbrushing enables fabrication of ACP-containing nanofiber scaffolds with controlled ion release.

Conclusions:

ACP polymeric composites offer tunable properties for hard tissue repair and regeneration.
Controlling material interfaces and polymer structures is key to optimizing performance.
ACP composites show promise for dental applications, particularly in remineralization.
ACP nanofiber scaffolds represent a novel platform for therapeutic delivery in precision medicine.